Critical elements of one of the most cited pieces of Alzheimer’s disease research in the last two decades may have been purposely manipulated, according to a report in Science.
Alzheimer’s is the most common cause of dementia globally, according to the World Health Organization. The highly influential paper, which was published in Nature in 2006, has helped guide billions of dollars in US federal government research into Alzheimer’s, according to Science.
The study, which looked at cognitive decline in mice, proposed that a specific amyloid protein may be responsible for cognitive decline. The hypothesis has since dominated the field, and researchers have worked for years to understand the mechanism by which such proteins may lead to decline.
But it goes on..
But a neuroscientist in Tennessee, Vanderbilt University professor Matthew Schrag, said in a Science article that he and other reviewers have identified as many as 10 papers on the protein that deserve deeper scrutiny. The report also cited other prominent researchers who have had difficulty replicating results of the studies on the specific proteins.
“I focus on what we can see in the published images, and describe them as red flags, not final conclusions,” he told Science, when revealing his role as a whistleblower. “The data should speak for itself.”
The heart of the matter is whether images in multiple papers were manipulated to better support a hypothesis, with the work of researcher Sylvain Lesné under particular examination. Lesné, an associate professor at the University of Minnesota, is now under investigation by the university.
His co-author on several papers is Dr Karen Ashe, also a University of Minnesota researcher and one of the most prominent Alzheimer’s researchers in the country. She described the potential manipulation of images as “devastating,” to the Minneapolis Star Tribune, but criticized the idea that her research into amyloid proteins singularly guided federal and drug company spending.
You can read the full story on the GUARDIAN..
There is a special place in hell for people who would be purposely in manipulation. Mistakes will happen. Sometimes a hypothesis will prove wrong–but it is a working guess..
However deliberant fraud in the face of a disease that wastes people away to an awful state? Unforgivable if true..
There was a certain scene from the Stephen King made for TV adaptation of STORM OF THE CENTURY.. IN one particular scene, Andre Linoge takes on the form of someone’s mom who was wasting away in a nursing home. She tells her son that he never came to visit her or cared for her before she died.. And she tells him hell is repetition. And when he got to hell his eyes would be eaten over, and over, and over again.
Perhaps that is the only comforting thing that could be said in the wake of this news..
Let’s start by being brutally honest: the Emmys in the Oscars and the Grammys don’t matter anymore. They are all 20th century relics. Their usefulness has run their course, and there from a time and place when pop-culture was given to us instead of us choosing what we wanted..
But there still is a bit of beauty in the dying arts of awards. And when we know that someone in a movie or a TV show or on an album really deserves an award and recognition for their performance, then getting that said award seems very justified.
Fast forward to today… the Emmy’s have gone upside down!
“Stranger Things” Season 4 garnered 13 Primetime Emmy nominations on Tuesday.
Emmy Nominations included Outstanding Drama Series, but acting nods for Sadie Sink and Millie Bobby Brown were not among them. The two “Stranger Things” stars were submitted in the supporting actress in a drama series category, but those eight noms instead went to Patricia Arquette (“Severance”), Julia Garner (“Ozark”), Jung Ho-yeon (“Squid Game”), Christina Ricci (“Yellowjackets”), Rhea Seehorn (“Better Call Saul”), J. Smith-Cameron (“Succession”), Sarah Snook (“Succession”) and Sydney Sweeney (“Euphoria”).
For those who have seen season four of Stranger Things, it can be arguably said that Sadie Sink carried the program. Yes, Millie Bobby Brown was amazing. Other than the cast for as well. But each and every time that Sadie appeared as Max on screen, the emotions would run high and her acting was impeccable.
And with these award nominations snubbing them both, it showcases how dramatically out of touch the Emmys are. And, it makes a mockery of their process.
According to the PSA, there are three important steps to take.
The first step is to “get inside” of a building fast and move away from any windows.
The second step is to “stay inside” and head into a basement if you have access to one. If you were outside during the nuclear blast, get clean immediately, removing and bagging all outer clothing to keep radioactive dust or ash away from your body.
The crack in the magnet field was created by a rare phenomenon called a co-rotating interaction region (CIR) from the Sun. CIRs are large-scale plasma structures generated in the low and mid-latitude regions of the heliosphere – the region surrounding the Sun that includes the solar magnetic field and the solar winds – when fast and slow-moving streams of solar wind interact.
— Read on www.iflscience.com/a-crack-opened-in-earths-magnetic-field-yesterday-and-stayed-open-for-14-hours-64372
While this article opens up it’s “journalism” with a crack about Vecna coming to the planet based off of this real life event, it at least goes on to explain that this is actually a very normal occurrence in cracks often open up the magnetic field..
The earth should probably start considering this: we need to gear up for what might be one of the most active periods of time right now for the sun between now and July 2025.
Maybe will get a couple beautiful aurora borealis nights deep in southern latitudes if these types of events continue
Major WWE news is sweeping the globe: Vince McMahon, the longtime leader of the wrestling entertainment federation, allegedly paid out more than $12 million in hush money over a 16 year span to women who accused him of sexual harassment..
Some more scoop on the scandal..
The payouts were made to four women, all of whom signed agreements that forbid them from disclosing any potential legal claims against McMahon, or their relationships with him..
Some more familiar with the issue tell the JOURNAL that there were previously unreported settlements stemming from incidents starting in 2005 when McMahon allegedly coerced a female wrestler to give him oral sex before demoting her and declining to renew her contract…
MORE..
The wrestler was retaliated against after she turned down further sexual advances from McMahon, and she was paid roughly $7.5 million in 2018 to keep quiet about the incidents, according to the Journal..
Elon Musk, the chief executive officer of Tesla and the world’s richest person, said on Friday he was terminating his $44 billion deal to buy Twitter because the social media company had failed to provide information about fake accounts.
In a filing, Musk’s lawyers said Twitter had failed or refused to respond to multiple requests for information on fake or spam accounts on the platform, which is fundamental to the company’s business performance.
“Twitter is in material breach of multiple provisions of that Agreement, appears to have made false and misleading representations upon which Mr. Musk relied when entering into the Merger Agreement,” the filing said.
A whole lot of shaking rattling and rolling is going on from South Carolina up to Maine and now even New Brunswick.
Well they do happen, they are certainly rare. Recent activity however seemingly has been on an uptick in a location of the country that really receives this many..
We know that the Georgia guide stones or destroyed. We know that the last remnants of the pillars that we’re still standing were taken down by an excavator. And we also know that 40 years of conspiracy theory, just like that, comes to a crashing end.
But new theories are igniting about whodunit!
Was it Cern?!
Lightning?!
God?!
The devil went down to Georgia!!
A new video is being shared which seems to show someone walking towards the guys stones. Law-enforcement agencies are stating that it is the same person who most likely set the bomb that eventually blew up early morning a few days back.
Some online have stated that a Christian fundamentalist group brought down the guide stones. Others are celebrating the destruction of what they called a possessed evil site…